Aseptic filtration for most fermentation broth is still using plate frame, drum, centrifuge, diatomaceous earth and other traditional separation equipment, or flocculation sedimentation, heating and isoelectric point precipitation and other methods.

These methods can only coarsely separate fermentation broth mycelium and other solids while a large number of soluble proteins, macromolecules and other organic matters are hard to separate resulting in low filtrate permeability .These residual insoluble and soluble impurities are one of the factors which have the greatest impact on the quality of final product and yield after extraction . At the same time, these traditional processes have the disadvantages of high labor intensity, low separation precision, low product yield, ,subsequent washing operation in large quantities and larger wastewater discharge .

The integrated membrane separation technology based on inorganic ceramic membrane "cross flow filtration" technology has gradually become one of the best ways to solve this problem with its unique separation advantages.